Abstract |
The value of aflatoxins is well known as a carcinogenic, mutagenic and teratogenic, likewise its association with the hepatitis B virus. In addition, it is known the incidence of hepatocellular carcinoma in such viral infection. A study was performed on the albumin adducts- aflatoxins levels in sera determined by ELISA method of children within 3-15 years old at the Service of Pediatric Gastroenterology from the National Institute of Gastroenterology. Samples consisted of 40 patients with chronic active hepatitis (CAH) B, 10 HBsAg+ carriers and 20 controls. The CAH group, showed a 32.5% of positiveness with a maximum levels of 25pg aflatoxin lysine/mg albumin while 20% of HBsAg positive carriers showed levels of un 12.3 pg aflatoxin lysine/mg albumin and 15% of the control group 5pg AF lysine/mg albumin. It can be observed that aflatoxin levels in patients of CAH presented values up to 5 times over the control group. This study suggest the validity of aflatoxin- albumin adducts as a marker of chronic exposure to this carcinogen and its importance in relation with the virus of hepatitis B.
|
Authors | M T Alvarez, C Castañeda, N Ruisanchez, M Aleaga, E García, M P Escobar |
Journal | G.E.N
(G E N)
1995 Jan-Mar
Vol. 49
Issue 1
Pg. 36-41
ISSN: 0016-3503 [Print] Venezuela |
Vernacular Title | Detección inmunológica de los aductos albumina-aflatoxina en niños con infección crónica por el virus de la hepatitis B. |
PMID | 8566671
(Publication Type: English Abstract, Journal Article)
|
Chemical References |
- Aflatoxins
- Hepatitis B Surface Antigens
- Serum Albumin
|
Topics |
- Adolescent
- Aflatoxins
(adverse effects, blood, urine)
- Child
- Child, Preschool
- Chronic Disease
- Hepatitis B
(blood)
- Hepatitis B Surface Antigens
(blood)
- Humans
- Metabolic Clearance Rate
- Serum Albumin
(analysis)
|