A biochemical study on combined treatment of experimental silicosis with tetradrine-PVNO and tetradrine-QOHP in rats.

Abstract

A better understanding is needed to explain the mechanism of therapeutic effect of combined use of tetradrine-PVNO and tetradrine-QOHP which play very important roles in treatment of silicosis. Blood prolidase (PLD), monamine oxidase (MAO) and plasminogen (PLG) in silicotic rats after treatment with tetradrine-PVNO or tetradrine-QOHP were measured. The values obtained were compared with the untreated silicotic rats. It was found that the silicotic rats that received tetradrine-PVNO showed significant increase in PLD and decrease in PLG, but no significant change in MAO. The PLD in plasma of silicotic rats that received tetradrine-QOHP were elevated significantly, but PLG and MAO did not change appreciably. These findings suggest that the combined use of tetradrine-PVNO and tetradrine-QOHP can accelerate the degradation of collagen in silicotic rats.

• Authors: L Yu, C Q Zhou, Y R Li, L Qu, K J Xing, Q C Du
• Journal: Biomedical and environmental sciences : BES (Biomed Environ Sci) Vol. 8 Issue 3 Pg. 265-8 (Sep 1995) ISSN: 0895-3988 [Print] China
• PMID: 8561927 (Publication Type: Journal Article)

Chemical References

• Alkaloids
• Benzylisoquinolines
• Piperazines
• tetrandrine
• Plasminogen
• Polyvinylpyridine N-Oxide
• Monoamine Oxidase
• Dipeptidases
• proline dipeptidase

Topics

• Alkaloids (administration & dosage, therapeutic use)
• Animals
• Benzylisoquinolines
• Dipeptidases (blood)
• Male
• Monoamine Oxidase (blood)
• Piperazines (administration & dosage, therapeutic use)
• Plasminogen (metabolism)
• Polyvinylpyridine N-Oxide (administration & dosage, therapeutic use)
• Rats
• Rats, Wistar
• Silicosis (blood, drug therapy, enzymology, metabolism)