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Ciprofloxacin vs. cefotaxime regimens for the treatment of intra-abdominal infections.

Abstract
The efficacy of ciprofloxacin plus metronidazole was compared with that of cefotaxime plus gentamicin plus metronidazole in 79 patients with proven intra-abdominal infections. Patients were classified with the Peritonitis Index Altona-II (PIA-II) score for severity of disease, underlying conditions, prognosis and type of infection. Local peritonitis was diagnosed in 21 patients, generalized peritonitis in 25, intra-abdominal abscesses in 33; 35 patients had polymicrobial infections. Cure and improvement rates were: ciprofloxacin 77%, cefotaxime combination 56% (p < 0.02). Failures were significantly associated with a low initial PIA-II score, the presence of generalized peritonitis or abscesses, persistence of pathogens and superinfection. Superinfection was observed in 49% of the cases under cefotaxime and in 30% under ciprofloxacin. Concentrations of ciprofloxacin in pus ranged 2.0-5.2 mg/l with simultaneous serum concentrations of 1.2-3.1 mg/l.
AuthorsJ A Hoogkamp-Korstanje
JournalInfection (Infection) 1995 Sep-Oct Vol. 23 Issue 5 Pg. 278-82 ISSN: 0300-8126 [Print] Germany
PMID8557385 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
Chemical References
  • Gentamicins
  • Metronidazole
  • Ciprofloxacin
  • Cefotaxime
Topics
  • Abdominal Abscess (drug therapy, microbiology)
  • Adult
  • Aged
  • Aged, 80 and over
  • Bacteria, Anaerobic (classification, drug effects, isolation & purification)
  • Bacterial Infections (drug therapy)
  • Cefotaxime (therapeutic use)
  • Ciprofloxacin (therapeutic use)
  • Drug Therapy, Combination
  • Female
  • Gentamicins (therapeutic use)
  • Humans
  • Male
  • Metronidazole (therapeutic use)
  • Middle Aged
  • Peritonitis (drug therapy, microbiology)
  • Treatment Outcome

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