Mazindol treatment for cocaine dependence.

Abstract

This double-blind placebo-controlled treatment study tested the efficacy of mazindol in currently cocaine-dependent out-patients. Forty-three patients were randomized to mazindol (2 mg QD) vs. placebo treatment for 6 weeks. All patients received weekly group counseling. Patients improved with respect to objective (urine toxicology) and subjective (self-report of times used, dollars spent, craving, etc.) measures. There was no response difference between patients treated with mazindol and those who received placebo.

• Authors: S M Stine, J H Krystal, T R Kosten, D S Charney
• Journal: Drug and alcohol dependence (Drug Alcohol Depend) Vol. 39 Issue 3 Pg. 245-52 (Oct 1995) ISSN: 0376-8716 [Print] Ireland
• PMID: 8556974 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Central Nervous System Stimulants
• Mazindol
• Cocaine

Topics

• Adult
• Central Nervous System Stimulants (adverse effects, therapeutic use)
• Cocaine (adverse effects)
• Double-Blind Method
• Female
• Humans
• Male
• Mazindol (adverse effects, therapeutic use)
• Neurologic Examination (drug effects)
• Substance Abuse Detection
• Substance Withdrawal Syndrome (rehabilitation)
• Substance-Related Disorders (rehabilitation)