Topical exposure to chlordane reduces the contact hypersensitivity response to oxazolone in BALB/c mice.
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| Abstract |
Previous studies have shown that prenatal exposure to the organochlorine pesticide chlordane significantly decreases the ear swelling response to the contact allergen oxazolone in BALB/c mice. Alterations of macrophage function in the efferent arm of the contact hypersensitivity response have also been reported. In the current study, chlordane was applied topically and the effects of oxazolone-induced contact hypersensitivity were determined. Initially, the reduction in oxazolone-induced ear swelling in topically-exposed female BALB/c mice was compared to 30-day-old BALB/c female mice exposed prenatally to chlordane. Prenatal chlordane exposure induced a 36% reduction in ear swelling compared to a 60% reduction following topical treatment at the challenge phase. Topically-applied chlordane also reduced the oxazolone-induced ear swelling by 40% when applied at sensitization. When applied at both sensitization and challenge, ear swelling was reduced by 71%. In a time-course study, it was determined that chlordane must be applied at the time of sensitization, challenge or both or within 1 h post-challenge to significantly reduce ear swelling. A dose-response study showed that the lowest concentration of chlordane resulting in a significantly reduced ear swelling response was 20 micrograms per ear.
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| Authors | B L Blaylock, K K Newsom, S D Holladay, B K Shipp, T A Bartow, H M Mehendale |
| Journal | Toxicology letters (Toxicol Lett) Vol. 81 Issue 2-3 Pg. 205-11 (Nov 15 1995) ISSN: 0378-4274 [Print] Netherlands |
| PMID | 8553376 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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