Abstract | OBJECTIVE: To review the literature investigating increased lipid concentrations in transplant recipients and the use of lipid-lowering agents in this population. DATA SOURCES: Relevant articles were identified from a MEDLINE search using the terms transplantation, hyperlipidemia, immunosuppression, and therapy including diet, gemfibrozil, bile acid sequestrants, nicotinic acid, probucol, and hydroxymethylglutaryl- coenzyme A ( HMG-CoA) reductase inhibitors. Selected literature, including controlled studies, was used in this review. STUDY SELECTION: Articles published since 1970 pertaining to hyperlipidemia in solid organ transplant recipients. Emphasis was placed on clinical trials that investigated approaches to the treatment of hyperlipidemia in transplant recipients. DATA EXTRACTION: Original articles and reviews were obtained to select material pertinent to the objectives. DATA SYNTHESIS: Descriptions of lipid concentrations in the transplant patient and treatment approaches used, including potential complications, were reviewed. CONCLUSIONS:
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Authors | J K Kirk, R E Dupuis |
Journal | The Annals of pharmacotherapy
(Ann Pharmacother)
Vol. 29
Issue 9
Pg. 879-91
(Sep 1995)
ISSN: 1060-0280 [Print] United States |
PMID | 8547738
(Publication Type: Journal Article, Review)
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Chemical References |
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Topics |
- Humans
- Hyperlipidemias
(drug therapy, etiology)
- Hypolipidemic Agents
(therapeutic use)
- Organ Transplantation
(adverse effects)
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