Field trials of ephemeral fever vaccines.

Abstract

Various bovine ephemeral fever (BEF) vaccines were tested between 1982 and 1984 in 24 Queensland herds; neutralising antibody responses were monitored and six of the herds were closely observed following natural challenge with ephemeral fever. A vaccine regime of two consecutive vaccinations with attenuated virus combined with the adjuvant Quil A provided excellent protection against BEF for at least 12 months, whereas one vaccination with the Quil A vaccine or two vaccinations with vaccine containing the adjuvant aluminium hydroxide gel did not provide significant protection. Antibody responses were highest for the vaccine incorporating Quil A when it was given as two consecutive injections. There was an apparent relationship between neutralising antibody response and the level of protection.

• Authors: B A Vanselow, J C Walthall, I Abetz
• Journal: Veterinary microbiology (Vet Microbiol) Vol. 46 Issue 1-3 Pg. 117-30 (Sep 1995) ISSN: 0378-1135 [Print] Netherlands
• PMID: 8545949 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adjuvants, Immunologic
• Antibodies, Viral
• Viral Vaccines

Topics

• Adjuvants, Immunologic
• Animals
• Antibodies, Viral (biosynthesis, blood)
• Antibody Formation
• Cattle
• Ephemeral Fever (immunology, prevention & control)
• Ephemeral Fever Virus, Bovine (immunology)
• Immunization Schedule
• Neutralization Tests
• Queensland
• Safety
• Vaccination
• Viral Vaccines (administration & dosage, adverse effects)