[Serum pepsinogen response to therapy for Helicobacter pylori associated gastro-duodenal disease].

Abstract

We investigated the effect of H. pylori therapy on serum concentrations of pepsinogens on 87 patients of gastro-duodenal disease. In addition, we intended to see whether serum pepsinogen can serve as markers of response to H. pylori eradication. In 48 successfully eradicated cases, there was a significant decrease in gastritis score, and was a significant fall in serum pepsinogen II (PG II) level, and was a significant increase in pepsinogen I/II ratio (PG I/II ratio). In contrast, no change in gastritis score, PG II, and PG I/II ratio were observed in 39 unsuccessfully eradicated patients. No change in serum pepsinogen I (PG I) level was observed in both groups. In provisional successfully eradicated cases in PG II of decrease greater than 30% in after treatment, there was a sensitivity of 83.3% and a specificity of 89.7%. For the PG I/II ratio of increased greater than 30% in after treatment, the sensitivity was 95.8%, and the specificity was 94.9%. These findings suggest that PG II, PG I/II ratio can be useful for clinical evaluation of eradication therapy.

• Authors: M Tokieda, K Kodama, A Ito, K Fujiyama, R Kodama, H Kawasaki, T Kubota, K Murakami, T Fujioka, M Nasu
• Journal: Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology (Nihon Shokakibyo Gakkai Zasshi) Vol. 92 Issue 11 Pg. 1825-31 (Nov 1995) ISSN: 0446-6586 [Print] Japan
• PMID: 8544351 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Biomarkers
• Pepsinogens

Topics

• Adolescent
• Adult
• Aged
• Anti-Bacterial Agents
• Biomarkers (blood)
• Drug Therapy, Combination (therapeutic use)
• Duodenal Ulcer (microbiology)
• Female
• Gastritis (drug therapy, microbiology)
• Helicobacter Infections
• Helicobacter pylori
• Humans
• Male
• Middle Aged
• Pepsinogens (blood)
• Sensitivity and Specificity
• Stomach Ulcer (microbiology)