Abstract | BACKGROUND: Many methods and medications had been tried for the treatment of chromoblastomycosis with unsatisfactory results. Recently, there were several reports showing a good response of chromoblastomycosis to itraconazole, but it took as long as 18-30 months for lesions to heal. METHODS: RESULTS: The 10 cases included five newly diagnosed and five recalcitrant cases. Two patients were cured by 200 mg/day alone within 3 months. Seven patients required itraconazole, 400 mg/day, with combined cryotherapy to cure the lesions within 5 to 10 months. One case showed marked improvement but no cure. After the period of 1-year follow-up, only one case had a recurrent infection. CONCLUSIONS:
Itraconazole was highly effective and may be useful in the treatment of chromoblastomycosis. A high dose is indicated in chronic fibrotic lesions in combination with liquid nitrogen cryotherapy, with higher efficacy and quicker healing than with medication alone.
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Authors | P Kullavanijaya, V Rojanavanich |
Journal | International journal of dermatology
(Int J Dermatol)
Vol. 34
Issue 11
Pg. 804-7
(Nov 1995)
ISSN: 0011-9059 [Print] England |
PMID | 8543418
(Publication Type: Journal Article)
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Chemical References |
- Antifungal Agents
- Itraconazole
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Antifungal Agents
(therapeutic use)
- Chromoblastomycosis
(pathology, therapy)
- Combined Modality Therapy
- Cryotherapy
- Humans
- Itraconazole
(therapeutic use)
- Male
- Middle Aged
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