Laser-excited fluorescence studies of mitochondrial function in saponin-skinned skeletal muscle fibers of patients with chronic progressive external ophthalmoplegia.

Abstract	The functional behavior of mitochondria in skeletal muscle of patients with chronic progressive external ophthalmoplegia was studied by laser-excited fluorescence measurements of NAD(P)H and flavoproteins in saponin-skinned fibers. Variations in the mitochondrial content and the presence of partially respiratory chain-inhibited mitochondria can be detected using this novel method.
Authors	K Winkler, A V Kuznetsov, H Lins, E Kirches, P von Bossanyi, K Dietzmann, B Frank, H Feistner, W S Kunz
Journal	Biochimica et biophysica acta (Biochim Biophys Acta) Vol. 1272 Issue 3 Pg. 181-4 (Dec 12 1995) ISSN: 0006-3002 [Print] Netherlands
PMID	8541350 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	DNA, Mitochondrial Flavoproteins Saponins NADP
Topics	DNA, Mitochondrial (genetics) Electron Transport Female Flavoproteins (metabolism) Fluorescence Humans Lasers Middle Aged Mitochondria, Muscle (enzymology, metabolism) Muscle Fibers, Skeletal (metabolism) NADP (metabolism) Ophthalmoplegia, Chronic Progressive External (metabolism) Oxidation-Reduction Oxygen Consumption Saponins

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