Abstract |
We measured, by RIA methods, ictal and interictal levels of substance P (SP), calcitonin-gene related peptide (CGRP) and neurokinin A (NKA) in the plasma of 30 young migraine patients with aura (MPA) and 45 migraine patients without aura (MWA), and compared the results with those of 30 age-matched controls. There were no significant differences between the levels of these vasoactive peptides in the control group and the levels in both migraine groups studied in headache-free periods. An elevation of CGRP levels in plasma was found during attacks in MPA and, to a lesser extent, in MWA (p < 0.03 and p < 0.05, respectively). A significant increase in NKA levels was also demonstrated in the MPA and MWA groups (p < 0.02 and p < 0.04, respectively). These data suggest, although indirectly, that CGRP and NKA could be involved in the pathogenesis of migraine attacks in juvenile migraine patients.
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Authors | V Gallai, P Sarchielli, A Floridi, M Franceschini, M Codini, G Glioti, A Trequattrini, R Palumbo |
Journal | Cephalalgia : an international journal of headache
(Cephalalgia)
Vol. 15
Issue 5
Pg. 384-90
(Oct 1995)
ISSN: 0333-1024 [Print] England |
PMID | 8536297
(Publication Type: Journal Article)
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Chemical References |
- Neuropeptides
- Substance P
- Neurokinin A
- Calcitonin Gene-Related Peptide
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Topics |
- Adolescent
- Calcitonin Gene-Related Peptide
(blood)
- Female
- Humans
- Male
- Migraine Disorders
(blood)
- Neurokinin A
(blood)
- Neuropeptides
(blood)
- Substance P
(blood)
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