Effect of senegin-II on blood glucose in normal and NIDDM mice.

The hypoglycemic effect of senegin-II, the main component of Polygala senega (Polygalaceae), was examined in normal and KK-Ay mice, one of the model animals of non-insulin-dependent diabetes mellitus (NIDDM). Senegin-II (2.5 mg/kg) reduced the level of blood glucose in normal mice from 220 +/- 8 to 131 +/- 5 mg/dl 4 hours after intraperitoneal administration (P < 0.001), and also significantly lowered the blood glucose of KK-Ay mice from 434 +/- 9 to 142 +/- 6 mg/dl under similar conditions (P < 0.001).
AuthorsM Kako, T Miura, M Usami, Y Nishiyama, M Ichimaru, M Moriyasu, A Kato
JournalBiological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 18 Issue 8 Pg. 1159-61 (Aug 1995) ISSN: 0918-6158 [Print] JAPAN
PMID8535417 (Publication Type: Journal Article)
Chemical References
  • Blood Glucose
  • Hypoglycemic Agents
  • Animals
  • Blood Glucose (drug effects)
  • Diabetes Mellitus, Type 2 (blood)
  • Disease Models, Animal
  • Hypoglycemic Agents (administration & dosage, pharmacology)
  • Injections, Intraperitoneal
  • Male
  • Mice
  • Plant Roots (chemistry)

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