Donor buffy coat infusions for a patient with myelodysplastic syndrome who relapsed following allogeneic bone marrow transplantation.

Abstract

A 49-year-old man with myelodysplastic syndrome (MDS, RAEB in T) who relapsed following allogeneic bone marrow transplantation (allo BMT) was treated with infusions of donor buffy coat leukocytes. He sustained hematologic and cytogenetic remission, but severe graft-versus-host disease (GVHD) developed for which cyclosporin A and prednisolone were required. This therapeutic approach appears to be valuable for relapsed MDS following allo BMT as well as for chronic myelogenous leukemia (CML).

• Authors: M Tsuzuki, F Maruyama, H Kojima, K Ezaki, M Hirano
• Journal: Bone marrow transplantation (Bone Marrow Transplant) Vol. 16 Issue 3 Pg. 487-9 (Sep 1995) ISSN: 0268-3369 [Print] England
• PMID: 8535326 (Publication Type: Case Reports, Journal Article)

Chemical References

• Cyclosporine
• Prednisolone

Topics

• Bone Marrow Transplantation (adverse effects)
• Cyclosporine (therapeutic use)
• Graft vs Host Disease (drug therapy)
• Humans
• Leukocyte Transfusion
• Male
• Middle Aged
• Myelodysplastic Syndromes (therapy)
• Prednisolone (therapeutic use)
• Recurrence