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Double isochromosome 8q as single cytogenetic aberration in acute myelo-monocytic leukemia.

Abstract
We report a case of double isochromosome 8q as a single cytogenetic abnormality in a patient with acute myelo-monocytic leukemia. Similarly to rare cases with tetrasomy 8, the patient showed monocytic involvement and was refractory to cytotoxic chemotherapy. We conclude that this kind of cytogenetic aberration is probably associated with distinct morphologic and clinical characteristics.
AuthorsL Vicari, L Sebastio, V Cirigliano, M T Pugliese, F Ferrara
JournalLeukemia & lymphoma (Leuk Lymphoma) Vol. 19 Issue 3-4 Pg. 351-3 (Oct 1995) ISSN: 1042-8194 [Print] United States
PMID8535230 (Publication Type: Case Reports, Journal Article)
Topics
  • Aneuploidy
  • Chromosome Aberrations (pathology)
  • Chromosome Banding
  • Chromosome Disorders
  • Chromosomes, Human, Pair 8
  • Female
  • Humans
  • In Situ Hybridization, Fluorescence
  • Leukemia, Myelomonocytic, Acute (pathology)
  • Middle Aged

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