Abstract | OBJECTIVE: DESIGN: A questionnaire-based follow-up at 12 and 18 months of age of cohorts of surviving children whose mothers participated in a large randomised, double-blind placebo-controlled trial of 60 mg aspirin. SETTING: United Kingdom and Ottawa, Canada. SUBJECTS: 4168 children assessed at 12 months through information provided by general practitioners, and 4365 assessed at 18 months through a questionnaire to parents. MAIN OUTCOME MEASURES: Hospital visits in the first 18 months for congenital malformations, motor deficit, developmental delay, respiratory problems or bleeding problems; height or weight below the third centile; and delayed acquisition of certain developmental skills. RESULTS: There were no clear differences in any of the main outcome measures, although some confidence intervals were wide. CONCLUSIONS: Although an adverse effect can not be ruled out, these findings are reassuring about the safety of low dose aspirin started after the first trimester, at least in respect of congenital malformations, major motor deficit, and severe neuromotor or developmental delay identifiable in early childhood. They provide no clear evidence of benefit. Taking into account evidence from large randomised controlled trials, the place of low-dose aspirin in pregnancy appears to be limited, although it may be beneficial for women at high risk of early onset pre-eclampsia; for them, evidence suggesting that it is not harmful is important.
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Authors | |
Journal | British journal of obstetrics and gynaecology
(Br J Obstet Gynaecol)
Vol. 102
Issue 11
Pg. 861-8
(Nov 1995)
ISSN: 0306-5456 [Print] England |
PMID | 8534620
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Aspirin
(administration & dosage, adverse effects)
- Body Height
- Body Weight
- Canada
(epidemiology)
- Cohort Studies
- Developmental Disabilities
(chemically induced, epidemiology)
- Double-Blind Method
- Female
- Fetal Growth Retardation
(prevention & control)
- Follow-Up Studies
- Hemorrhage
(epidemiology)
- Hospitalization
- Humans
- Infant
- Pre-Eclampsia
(prevention & control)
- Pregnancy
- Prenatal Exposure Delayed Effects
- Respiration Disorders
(epidemiology)
- United Kingdom
(epidemiology)
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