Abstract |
nm23 gene expression has been shown to be inversely correlated with tumour metastatic potential in some cancers but not in others. Examination was made of the expression of nm23-H1 and nm23-H2 gene products by immunohistochemistry and immunoblotting in 28 endometrial carcinomas. Immunohistochemistry indicated the cytoplasm of cancer cells to be positive, and myometrium and endometrial stromal cells negative, for nm23-H1 and -H2 protein. The staining intensity for these proteins was significantly stronger in well-differentiated adenocarcinomas (G1) than in those moderately differentiated (G2) (P < 0.05). nm23-H1 and -H2 proteins were shown by immunoblotting to be present at significantly higher levels in G1 than in G2 tumours (P < 0.05). Two of eight cases expressed high nm23-H1 and -H2 protein in poorly differentiated adenocarcinomas (G3). In G3 tumours, nm23 expression may be diverse. In this study, the expression of nm23-H1 and -H2 was not correlated with stage, metastasis, tumour size, myometrial invasion, oestrogen receptor, progesterone receptor or menopause. It follows from the findings presented above that the high expression of nm23-H1 and -H2 is positively correlated with histological differentiation.
|
Authors | J Watanabe, Y Sato, H Kuramoto, T Kameya |
Journal | British journal of cancer
(Br J Cancer)
Vol. 72
Issue 6
Pg. 1469-73
(Dec 1995)
ISSN: 0007-0920 [Print] England |
PMID | 8519661
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- NM23 Nucleoside Diphosphate Kinases
- Receptors, Estrogen
- Receptors, Progesterone
- Transcription Factors
- NME1 protein, human
- Nme1 protein, mouse
- Nucleoside-Diphosphate Kinase
- Monomeric GTP-Binding Proteins
|
Topics |
- Adult
- Aged
- Aged, 80 and over
- Animals
- Cell Differentiation
(physiology)
- Endometrial Neoplasms
(chemistry, pathology, ultrastructure)
- Female
- Humans
- Immunoblotting
- Immunohistochemistry
- Menopause
- Mice
- Middle Aged
- Monomeric GTP-Binding Proteins
- NM23 Nucleoside Diphosphate Kinases
- Neoplasm Metastasis
- Nucleoside-Diphosphate Kinase
(biosynthesis)
- Receptors, Estrogen
(analysis)
- Receptors, Progesterone
(analysis)
- Transcription Factors
(biosynthesis)
|