Neural tolerance of the non-ionic dimers iodixanol and iotrolan and the non-ionic monomer iopamidol during myelography in non-anaesthetised rabbits.

Abstract

PURPOSE:

The neural tolerance of the recently introduced dimer iodixanol (320 g I/l) was compared with that of the dimer iotrolan (300 g I/l) and of the monomer iopamidol (300 g I/l), both used in clinical myelography.

MATERIAL AND METHODS:

Non-anaesthetised rabbits were injected into the cisterna magna with Ringer's solution (control) or contrast media (CM) at doses of 1.0 or 0.5 ml/kg b.w. The behaviour of the animals (10 in each of 7 groups) was evaluated for signs of excitation and depression during the first 3 hours after injection.

RESULTS:

At the dose level of 1.0 ml/kg b.w., iodixanol produced no seizures but did cause focal twitching in 4/10 rabbits. Iopamidol produced grand mal seizures in 2/10 and hyperexcitability in 4/10 rabbits. Iotrolan produced generalised grand mal seizures in 8/10 rabbits, an incidence of excitation significantly greater than that of iodixanol (p < 0.01) and iopamidol (p < 0.05). The excitative effects of iodixanol were not significantly different from those of iopamidol and Ringer's solution. All 3 CM produced similar depressive effects on rabbit behaviour. Ringer's solution caused no depressive effects (p < 0.01). A clear dose response was produced with all 3 CM after treatment with a lower dose of 0.5 ml/kg b.w.

CONCLUSION:

The results indicate that the neural tolerance in the rabbit of iodixanol is higher than that of iotrolan, and is at least equal to that of iopamidol.

• Authors: P Maly, P Sundgren, L Bååth, P Walday
• Journal: Acta radiologica (Stockholm, Sweden : 1987) (Acta Radiol) Vol. 36 Issue 6 Pg. 644-8 (Nov 1995) ISSN: 0284-1851 [Print] England
• PMID: 8519577 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Contrast Media
• Triiodobenzoic Acids
• iotrolan
• iodixanol
• Iopamidol

Topics

• Animals
• Behavior, Animal (drug effects)
• Contrast Media (toxicity)
• Iopamidol (toxicity)
• Myelography
• Nervous System (drug effects)
• Rabbits
• Seizures (diagnosis)
• Triiodobenzoic Acids (toxicity)