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Melanotic neuroectodermal tumor of infancy: its histological similarities to fetal pineal gland.

Abstract
Striking similarities between the pineals of 107 fetuses and infants and a pigmented neuroectodermal tumor occurring in the right orbital and right frontal regions in a 6-month-old Puerto Rican boy were found. Both the human fetal pineal and melanotic neuroectodermal tumors of infancy are characterized by pigmented (melanin) epithelial cells, small undifferentiated cells, and a fibrovascular stroma. Our findings suggest the fetal pineal may be a normally occurring precursor of the melanotic neuroectodermal tumor of infancy, or that melanin production may be a normal capability of differentiating neuroepithelial cells.
AuthorsE C Dooling, J G Chi, F H Gilles
JournalCancer (Cancer) Vol. 39 Issue 4 Pg. 1535-41 (Apr 1977) ISSN: 0008-543X [Print] United States
PMID851944 (Publication Type: Case Reports, Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Melanins
Topics
  • Child, Preschool
  • Epithelial Cells
  • Epithelium (pathology)
  • Female
  • Frontal Lobe
  • Gestational Age
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Melanins (biosynthesis)
  • Orbital Neoplasms (embryology, metabolism, pathology)
  • Pineal Gland (embryology, metabolism)

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