Abstract |
Striking similarities between the pineals of 107 fetuses and infants and a pigmented neuroectodermal tumor occurring in the right orbital and right frontal regions in a 6-month-old Puerto Rican boy were found. Both the human fetal pineal and melanotic neuroectodermal tumors of infancy are characterized by pigmented ( melanin) epithelial cells, small undifferentiated cells, and a fibrovascular stroma. Our findings suggest the fetal pineal may be a normally occurring precursor of the melanotic neuroectodermal tumor of infancy, or that melanin production may be a normal capability of differentiating neuroepithelial cells.
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Authors | E C Dooling, J G Chi, F H Gilles |
Journal | Cancer
(Cancer)
Vol. 39
Issue 4
Pg. 1535-41
(Apr 1977)
ISSN: 0008-543X [Print] United States |
PMID | 851944
(Publication Type: Case Reports, Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
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Topics |
- Child, Preschool
- Epithelial Cells
- Epithelium
(pathology)
- Female
- Frontal Lobe
- Gestational Age
- Humans
- Infant
- Infant, Newborn
- Male
- Melanins
(biosynthesis)
- Orbital Neoplasms
(embryology, metabolism, pathology)
- Pineal Gland
(embryology, metabolism)
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