Dyspepsia and dyspepsia subgroups in Japan: symptom profiles and experience with cisapride.

Abstract

In 240 patients with symptoms of dyspepsia, recruited consecutively and investigated in 12 hospitals in Japan, 24.2% were diagnosed having organic dyspepsia; 75.8% had functional dyspepsia, of whom 63.2% were diagnosed by the investigator having dysmotility-like, 13.7% ulcer-like, 11.5% reflux-like, and 11.5% non-specific dyspepsia. There was, however, considerable overlap of symptom profiles. Cisapride therapy initiated in functional dyspeptic patients resulted in moderate or marked improvement in 79.1% of the patients with the highest response rates for dysmotility-like (85.2%), reflux-like (81.0%), and non-specific dyspepsia (76.1%) (versus 52.0% for ulcer-like dyspepsia).

• Authors: M Inoue, T Sekiguchi, S Harasawa, T Miwa, A Miyoshi
• Journal: Scandinavian journal of gastroenterology. Supplement (Scand J Gastroenterol Suppl) Vol. 195 Pg. 36-8; discussion 38-9 ( 1993) ISSN: 0085-5928 [Print] England
• PMID: 8516656 (Publication Type: Journal Article, Multicenter Study)

Chemical References

• Piperidines
• Cisapride

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Child
• Cisapride
• Dyspepsia (classification, drug therapy, physiopathology)
• Female
• Gastrointestinal Motility (drug effects)
• Humans
• Japan
• Male
• Middle Aged
• Piperidines (therapeutic use)
• Treatment Outcome