The proto-oncogene c-fms is overexpressed in endometrial cancer.

Abstract

Recent studies have shown that macrophage colony-stimulating factor and its receptor c-fms protein are significantly overexpressed in endometrial and ovarian cancers. In the present study, we analyzed the steady-state levels of c-fms mRNA in benign and malignant endometrial tissues by Northern and slot blot analyses. The relative levels of c-fms mRNA were quantified by using a hybridization signal for each sample on Northern blot analysis. Slot blot analysis was used to further quantitate the relative increase in c-fms mRNA in malignant specimens compared to benign specimens. Correlation of c-fms expression in the endometrial cancers was made with traditional prognostic indicators. Secretory endometrium had low levels of c-fms mRNA, whereas the endometrial cancers had the highest levels. Proliferative and hyperplastic endometrium values were intermediate. Comparative assessment of c-fms expression in endometrial cancer relative to other prognostic factors demonstrated greater expression of c-fms in specimens from patients with abnormal DNA ploidy, high-grade lesions, and possibly extrauterine metastases. Our study confirms the overexpression of c-fms in endometrial cancer and demonstrates a positive correlation between the steady-state mRNA levels of c-fms and other select adverse prognostic indicators.

• Authors: G S Leiserowitz, S A Harris, M Subramaniam, G L Keeney, K C Podratz, T C Spelsberg
• Journal: Gynecologic oncology (Gynecol Oncol) Vol. 49 Issue 2 Pg. 190-6 (May 1993) ISSN: 0090-8258 [Print] United States
• PMID: 8504987 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• MAS1 protein, human
• Proto-Oncogene Mas
• RNA, Messenger
• RNA, Neoplasm

Topics

• Endometrial Neoplasms (genetics)
• Endometrium (metabolism)
• Female
• Gene Expression Regulation, Neoplastic
• Genes, fms
• Humans
• Ploidies
• Prognosis
• Proto-Oncogene Mas
• RNA, Messenger (analysis)
• RNA, Neoplasm (analysis)