Effectiveness of sodium 4,5-dihydroxybenzene-1,3-disulfonate (Tiron) in protecting against uranium-induced developmental toxicity in mice.

Abstract

The effect of Tiron (sodium 4,5-dihydroxybenzene-1,3-disulfonate), a chelating agent used in the treatment of experimental poisoning by a number of heavy metals, on uranium-induced developmental toxicity was evaluated in Swiss mice. A series of four Tiron injections was administered intraperitoneally to pregnant mice immediately after a single subcutaneous injection of 4 mg/kg of uranyl acetate dihydrate given on day 10 of gestation and at 24, 48, and 72 h thereafter. Controls received 0.9% saline with or without uranyl acetate. Tiron effectiveness was assessed at 500, 1000 and 1500 mg/kg per day. Amelioration by Tiron of uranium-induced embryolethality was not noted at the two lower doses. The percentage of dead and resorbed fetuses in the Tiron-treated groups was not statistically different from that in the positive control group. However, treatment at 1500 mg/kg per day showed isolated protective effects against uranium fetotoxicity, such as that evidenced by the lack of differences in fetal body weight between this group and the uranium-untreated group, as well as by a decrease in the number of skeletal defects. According to these results, the ability of Tiron to protect the developing mouse fetus against uranium-induced developmental toxicity offers only modest encouragement with regard to its possible therapeutic potential for pregnant women exposed to this metal.

• Authors: M A Bosque, J L Domingo, J M Llobet, J Corbella
• Journal: Toxicology (Toxicology) Vol. 79 Issue 2 Pg. 149-56 (Apr 30 1993) ISSN: 0300-483X [Print] Ireland
• PMID: 8497868 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Organometallic Compounds
• uranyl acetate
• Uranium
• 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt

Topics

• 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt (therapeutic use)
• Abnormalities, Drug-Induced (etiology, prevention & control)
• Animals
• Female
• Fetal Death (chemically induced, prevention & control)
• Fetal Resorption (chemically induced, prevention & control)
• Injections, Subcutaneous
• Male
• Mice
• Organometallic Compounds (administration & dosage, toxicity)
• Pregnancy
• Uranium (toxicity)