Unilateral linear lichenoid eruption after bone marrow transplantation: an unmasking of tolerance to an abnormal keratinocyte clone?

Abstract

Chronic cutaneous graft-versus-host disease may appear clinically as a lichenoid eruption. We describe a 26-year-old man who developed a unilateral linear lichenoid eruption 7 months after allogeneic bone marrow transplantation. We believe this represents an unusual form of localized, chronic graft-versus-host disease. The possible relationship to viral infection or cellular mosaicism and the clinical, histologic, and immunologic similarities to idiopathic lichen planus are discussed.

• Authors: B Beers, R S Kalish, V N Kaye, M V Dahl
• Journal: Journal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 28 Issue 5 Pt 2 Pg. 888-92 (May 1993) ISSN: 0190-9622 [Print] United States
• PMID: 8491888 (Publication Type: Case Reports, Journal Article)

Topics

• Adult
• Bone Marrow Transplantation (adverse effects)
• Clone Cells
• Graft vs Host Disease (etiology, immunology, pathology)
• Humans
• Immune Tolerance
• Keratinocytes (immunology, pathology)
• Keratosis (pathology)
• Lichenoid Eruptions (etiology, immunology, pathology)
• Male