Abstract |
The effect of riboflavin deficiency on gastrointestinal Fe distribution and loss was studied in weanling rats. Riboflavin deficiency was associated with a significant increase in crypt depth in the upper and mid small intestine and a twofold increase in the rate of crypt cell production compared with weight-matched and ad lib.-fed control rats. The rate of loss of endogenous Fe, measured as faecal 59Fe after intraperitoneally administered 59Fe, was twice that from riboflavin-deficient rats compared with weight-matched controls. We suggest that while there may be a contribution from turnover of enterocytes with an enhanced Fe content, enhanced Fe loss associated with riboflavin deficiency is due predominantly to an accelerated rate of small-intestinal epithelial turnover.
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Authors | H J Powers, L T Weaver, S Austin, J K Beresford |
Journal | The British journal of nutrition
(Br J Nutr)
Vol. 69
Issue 2
Pg. 553-61
(Mar 1993)
ISSN: 0007-1145 [Print] England |
PMID | 8490008
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
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Topics |
- Animals
- Cell Division
(physiology)
- Female
- Intestinal Absorption
(physiology)
- Intestine, Small
(metabolism, pathology)
- Iron
(metabolism)
- Rats
- Rats, Inbred Strains
- Riboflavin Deficiency
(metabolism)
- Weaning
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