Abstract |
The elimination of cefmenoxime after single and repeated i.v. dosing was studied in 12 patients with severe renal failure and sepsis during continuous haemofiltration. More than 30% of the drug was found in the filtrate. The sieving coefficient (S) was 0.54. Vss% was unchanged 0.31 l.kg-1 in comparison with patients with normal renal function, whereas the mean t1/2ss was prolonged to about 16 h, and total clearance was reduced 20.8 ml.min-1.1.73 m-2. Once daily administration of 1 g cefmenoxime is suggested as the appropriate dose under such circumstances.
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Authors | J Evers, K Borner, P Koeppe |
Journal | European journal of clinical pharmacology
(Eur J Clin Pharmacol)
Vol. 44 Suppl 1
Pg. S31-2
( 1993)
ISSN: 0031-6970 [Print] Germany |
PMID | 8486144
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Cefmenoxime
(administration & dosage, pharmacokinetics)
- Chromatography, High Pressure Liquid
- Female
- Half-Life
- Hemofiltration
- Humans
- Kidney Failure, Chronic
(metabolism, therapy)
- Male
- Middle Aged
- Regression Analysis
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