Abstract |
Apolipoprotein E ( apo E) is a protein constituent of several plasma lipoproteins. Its major physiological role is to mediate the interaction of these lipoproteins and receptors. Three common apo E alleles and six phenotypes are known. The phenotype E2/E2 is associated with type III hyperlipoproteinemia. As a consequence of the increasing clinical interest in apo E phenotypes, especially in relation to the diagnosis of type III hyperlipoproteinemia, we have established a method for apo E phenotyping. Allele frequencies from a population of 211 healthy individuals are presented. The results show that, like as in Finland and Sweden the e4 allele is more frequent than in non-Nordic countries.
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Authors | T A Hagve, T Furuset, B Christophersen, L Ose |
Journal | Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke
(Tidsskr Nor Laegeforen)
Vol. 113
Issue 7
Pg. 853-6
(Mar 10 1993)
ISSN: 0029-2001 [Print] Norway |
Vernacular Title | Apolipoprotein E-fenotyping--nyttig ved utredning av hyperlipoproteinemi type III. |
PMID | 8480294
(Publication Type: Case Reports, English Abstract, Journal Article)
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Chemical References |
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Topics |
- Adult
- Apolipoproteins E
(genetics)
- Humans
- Hyperlipoproteinemia Type III
(diagnosis, genetics, pathology)
- Immunoblotting
- Isoelectric Focusing
- Male
- Phenotype
- Xanthomatosis
(blood, genetics, pathology)
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