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Splenectomy in human immunodeficiency virus-related thrombocytopenia.

Abstract
To evaluate the efficacy and safety of splenectomy in patients with human immunodeficiency virus (HIV)-related thrombocytopenia, 30 HIV-infected patients with thrombocytopenia (platelet count < 50 x 10(9)/l) who underwent splenectomy were followed prospectively for a mean period of 42 months. There were no perioperative deaths and morbidity was minimal. Twenty-one patients had a persistent complete response, six had a partial response and were asymptomatic after splenectomy, and only three showed no response. Three patients developed acquired immune deficiency syndrome during follow-up, an incidence that was no different from that expected. Splenectomy is a safe and effective treatment in HIV-infected patients with severe symptomatic thrombocytopenic purpura resistant to medical therapy.
AuthorsM Alonso, D Gossot, E Bourstyn, M J Galera, E Oksenhendler, M Celerier, P Clot
JournalThe British journal of surgery (Br J Surg) Vol. 80 Issue 3 Pg. 330-3 (Mar 1993) ISSN: 0007-1323 [Print] England
PMID8472143 (Publication Type: Journal Article, Review)
Topics
  • Adolescent
  • Adult
  • Female
  • Follow-Up Studies
  • HIV Infections (complications)
  • Humans
  • Male
  • Platelet Count
  • Prospective Studies
  • Splenectomy
  • Thrombocytopenia (complications, surgery)

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