OBJECTIVE: DESIGN, SETTING AND PARTICIPANTS: Various drug regimens given to four groups of healthy male members of the Australian Army during training exercises in malarious countries. INTERVENTIONS: Four groups of soldiers were given different regimens for 3-12 weeks: Group 1--mefloquine (250 mg weekly); Group 2--doxycycline (100 mg daily); Group 3--doxycycline (100 mg daily) and primaquine (7.5 mg daily); and Group 4--doxycycline (50 mg daily) and chloroquine (300 mg weekly). Except in Group 3, each of these regimens was followed by a 7.5 mg dose of primaquine three times a day for two weeks. MAIN OUTCOME MEASURES: The proportion of participants in the various prophylactic drug groups who developed falciparum or vivax malaria during or after the intervention. RESULTS: CONCLUSIONS:
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