Abstract | BACKGROUND: METHODS: Twenty-seven patients underwent functional grading, sigmoidoscopic and histological scoring, 111In-labeled granulocyte scanning, and 4-day fecal collections for 111In-labeled granulocyte excretion. Six of the patients with pouchitis underwent repeat studies after 1-month treatment with metronidazole, 400 mg three times daily. RESULTS: The grade of macroscopic inflammation in the pouch mucosa (sigmoidoscopic score) correlated well with the acute histological score (P < 0.0001), chronic histological score (P < 0.001), 4-hour 111In scan (P < 0.001), 24-hour 111In scan (P < 0.001), and with 4-day fecal 111In excretion (P < 0.001). After metronidazole therapy there was decreased inflammatory grade sigmoidoscopically and histologically on the 4- and 24-hour scans and decreased 4-day fecal 111In granulocyte excretion. CONCLUSIONS: This study confirms that the inflammatory infiltrate in pouchitis is acute or chronic, is characterized by neutrophils, is usually localized to pouch mucosa, and is always decreased after metronidazole therapy.
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Authors | W A Kmiot, S R Hesslewood, N Smith, H Thompson, L K Harding, M R Keighley |
Journal | Gastroenterology
(Gastroenterology)
Vol. 104
Issue 4
Pg. 981-8
(Apr 1993)
ISSN: 0016-5085 [Print] United States |
PMID | 8462824
(Publication Type: Journal Article)
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Chemical References |
- Indium Radioisotopes
- Metronidazole
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Topics |
- Acute Disease
- Biopsy
- Chronic Disease
- Gastrointestinal Hemorrhage
(etiology, pathology)
- Granulocytes
(pathology, physiology)
- Humans
- Indium Radioisotopes
- Inflammation
(drug therapy, physiopathology)
- Intestinal Mucosa
(pathology)
- Metronidazole
(therapeutic use)
- Proctocolectomy, Restorative
(adverse effects)
- Sigmoidoscopy
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