[Serologic monitoring of patients with endometrial carcinoma using ovarian carcinoma antigen (CA 125)].

Abstract

The serum concentrations of CA 125 were determined in 136 corpus carcinoma patients. Before the primary irradiation therapy in 40.2% (19/47), after the hysterectomy 3.4% (3/89) of the patients had elevated (> 35 U/ml) CA 125 levels. CA 125 values above the normal range were frequently associated with advanced stages. Measuring elevated levels after hysterectomy proved bad prognosis. There were no correlation of CA 125 levels and degree of the histological type and differentiation of the tumor. Serological follow up revealed a correlation with the clinical course of the endometrial carcinoma in 62% (31/50). 18 cases who had tumor progression associated rising CA 125 levels. In 10 patients with tumor progression the CA 125 levels increased before clinical sign of progression with a median lead time of one month. The determination of CA 125 is recommended to check the endometrial carcinoma patients and to detect progression of the tumor.

• Authors: P Göcze, H Varhson
• Journal: Orvosi hetilap (Orv Hetil) Vol. 134 Issue 13 Pg. 685-8 (Mar 28 1993) ISSN: 0030-6002 [Print] Hungary
• Vernacular Title: Endometrium carcinomás betegek szerológiai ellenörzése ovarium carcinoma antigénnel (CA 125).
• PMID: 8460017 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antigens, Neoplasm
• Carcinoembryonic Antigen
• ovarian tumor associated antigen

Topics

• Antigens, Neoplasm (immunology)
• Carcinoembryonic Antigen (immunology)
• Combined Modality Therapy
• Female
• Humans
• Immunohistochemistry
• Monitoring, Immunologic
• Ovarian Neoplasms (immunology, pathology, therapy)