Abstract | OBJECTIVE: The aim was to study the mechanism of global hypoxia induced atrioventricular (AV) nodal conduction block in vivo using a guinea pig model. METHODS: RESULTS: Progressive incremental hypoxia was associated with progressive AV nodal conduction delay culminating in a complete block. In addition, there was an inverse relationship between the severity of hypoxia and time to AV nodal block. Both N0861 and pertussis toxin treatment significantly reduced the degree of hypoxia induced AV nodal conduction block and delayed its appearance. CONCLUSIONS:
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Authors | J Xu, H Tong, L Wang, C M Hurt, A Pelleg |
Journal | Cardiovascular research
(Cardiovasc Res)
Vol. 27
Issue 1
Pg. 134-40
(Jan 1993)
ISSN: 0008-6363 [Print] England |
PMID | 8458024
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Norbornanes
- Purinergic Antagonists
- Receptors, Purinergic
- Virulence Factors, Bordetella
- N 0861
- Pertussis Toxin
- GTP-Binding Proteins
- Adenine
- Adenosine
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Topics |
- Adenine
(analogs & derivatives, pharmacology)
- Adenosine
(metabolism)
- Animals
- Female
- GTP-Binding Proteins
(metabolism)
- Guinea Pigs
- Heart
(drug effects)
- Heart Block
(etiology, metabolism, prevention & control)
- Male
- Myocardial Ischemia
(complications, metabolism)
- Norbornanes
(pharmacology)
- Pertussis Toxin
- Purinergic Antagonists
- Receptors, Purinergic
(metabolism)
- Virulence Factors, Bordetella
(pharmacology)
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