Abstract |
Three hundred fifty six patients aged 65 years or more (mean age 81.8 years) who were suffering from chronic bronchitis were included in a double-blind trial against placebo to assess the preventative effect of OM-85 BV against acute exacerbations of chronic bronchitis. OM-85 BV is an immunostimulant composed of lyophilised factions of 8 bacteria which are most frequently encountered during the course of respiratory tract infections. 291 patients completed the study. In the group treated by OM-85 BV, a significant increase in the number of patients with no episode of acute bronchitis was noted (96 versus 71, p = 0.006). There was a 38.8% reduction in the absolute numbers of episodes of acute bronchitis and a 33% reduction in the number of prescriptions for antibiotics, however there was no difference in the number of pneumonias and bronchopneumonias. These results show the protective effect of OM-85 BV against bronchial superinfections in a large population of elderly patients suffering from chronic bronchitis.
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Authors | B Orcel, B Delclaux, M Baud, J P Derenne |
Journal | Revue des maladies respiratoires
(Rev Mal Respir)
Vol. 10
Issue 1
Pg. 23-8
( 1993)
ISSN: 0761-8425 [Print] France |
Vernacular Title | Effet préventif d'un immunomodulateur, l'OM-85 BV, sur les exacerbations aiguës de bronchite chronique du sujet âgé. Résultats préliminaires à 6 mois chez 291 patients. |
PMID | 8451491
(Publication Type: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Adjuvants, Immunologic
- Broncho-Vaxom
- Cell Extracts
- Immunoglobulins
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Topics |
- Acute Disease
- Adjuvants, Immunologic
(administration & dosage, pharmacology, therapeutic use)
- Aged
- Bacteria
- Blood Cell Count
- Blood Gas Analysis
- Bronchitis
(complications, diagnosis, drug therapy)
- Cell Extracts
- Chronic Disease
- Double-Blind Method
- Female
- Humans
- Immunoglobulins
(blood)
- Incidence
- Male
- Middle Aged
- Paris
(epidemiology)
- Prospective Studies
- Respiratory Tract Infections
(epidemiology, etiology, prevention & control)
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