HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Effect of erythromycin on neutrophil adhesion molecules].

Abstract
The mechanisms of erythromycin (EM) in chronic lower respiratory tract diseases including diffuse panbronchiolitis (DPB) has been reported. In this study we investigated the effect of EM on peripheral neutrophil adhesion molecules such as LFA-1 and Mac-1 obtained from six healthy subjects. Pretreatment of neutrophils with each concentration (10 ng/ml approximately 100 micrograms/ml) of EM resulted in no significant reduction in the expression of LFA-1 alpha, beta and Mac-1. Moreover, EM had no capability of reducing these expressions even when neutrophils were pretreated with 1 microgram/ml of EM at time from 0 to 60 min. These findings indicate that EM does not directly reduce the expression of LFA-1 alpha, beta and Mac-1 on peripheral neutrophil obtained from healthy subjects.
AuthorsS Kusano, H Mukae, T Morikawa, T Asai, H Sawa, N Morikawa, H Oda, O Sakito, C Shukuwa, R Senju
JournalKansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases (Kansenshogaku Zasshi) Vol. 67 Issue 1 Pg. 7-11 (Jan 1993) ISSN: 0387-5911 [Print] Japan
PMID8450276 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Cell Adhesion Molecules
  • Lymphocyte Function-Associated Antigen-1
  • Erythromycin
Topics
  • Adult
  • Cell Adhesion Molecules (drug effects)
  • Cells, Cultured
  • Dose-Response Relationship, Drug
  • Erythromycin (pharmacology)
  • Humans
  • Lymphocyte Function-Associated Antigen-1 (drug effects)
  • Male
  • Neutrophils (drug effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: