Heinz body hemolytic anemia induced by DQ-2511, a new anti-ulcer drug, in dogs.

Abstract

DQ-2511, a new anti-ulcer drug, was administered to beagle dogs for 4 weeks to investigate the mechanism whereby this drug induced hemolytic anemia and its reversibility in comparison with beta-acetylphenylhydrazine. Hemolytic anemia accompanied by an increase in the number of cells containing Heinz bodies that was preceded by a marked decrease in blood-reduced glutathione concentration was observed in dogs receiving 600 mg/kg of DQ-2511, but only a slight increase in the methemoglobin level was noted. beta-Acetylphenylhydrazine, however, caused hemolytic anemia accompanied by marked increases in both Heinz body-containing cells and methemoglobin concentration, but the blood-reduced glutathione concentration was not decreased consistently with the formation of Heinz bodies. Hemolytic anemia disappeared after a 4-week recovery period in the dogs that received DQ-2511. These results suggest that decreases in reduced glutathione in erythrocytes play an important role in the anemia and Heinz body formation induced by DQ-2511, but not by beta-acetylphenylhydrazine.

• Authors: H Ohno, H Tojo, K Kakihata, M Nomura, S Takayama
• Journal: Fundamental and applied toxicology : official journal of the Society of Toxicology (Fundam Appl Toxicol) Vol. 20 Issue 2 Pg. 141-6 (Feb 1993) ISSN: 0272-0590 [Print] United States
• PMID: 8449384 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Anti-Ulcer Agents
• Benzamides
• Hemoglobins
• Phenylhydrazines
• ecabapide
• N(1)-acetylphenylhydrazine
• Glutathione

Topics

• Administration, Oral
• Anemia, Hemolytic (blood, chemically induced)
• Animals
• Anti-Ulcer Agents (toxicity)
• Benzamides (toxicity)
• Dogs
• Dose-Response Relationship, Drug
• Erythrocyte Count (drug effects)
• Erythrocytes (drug effects, metabolism)
• Glutathione (blood)
• Heinz Bodies (drug effects)
• Hematocrit
• Hemoglobins (analysis, drug effects)
• Male
• Phenylhydrazines (toxicity)