Abstract |
Nearly mature newborn rabbits (gestational age 29.5 days) were tracheotomized at birth and received, via the tracheal cannula, 6 ml/kg body weight of a filtered saline suspension of human meconium, 65 or 130 mg/ml. Animals were kept in body plethysmographs and ventilated for 60 min with standardized tidal volume (8-10 ml/kg). Aspiration of meconium caused, in both groups, a statistically significant reduction in lung-thorax compliance, elevated PCO2 in heart blood and reduced alveolar volume density (VV) in histological sections. Both groups responded to treatment with exogenous surfactant ( Curosurf, 200 mg/kg) with a moderate, statistically significant improvement in lung-thorax compliance, PCO2 and alveolar VV. Our data indicate that respiratory failure after neonatal meconium aspiration may be influenced favorably by treatment with exogenous surfactant.
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Authors | B Sun, T Curstedt, G W Song, B Robertson |
Journal | Biology of the neonate
(Biol Neonate)
Vol. 63
Issue 2
Pg. 96-104
( 1993)
ISSN: 0006-3126 [Print] Switzerland |
PMID | 8448260
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Pulmonary Surfactants
- Carbon Dioxide
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Topics |
- Animals
- Animals, Newborn
(physiology)
- Carbon Dioxide
(blood)
- Humans
- Infant, Newborn
- Lung
(pathology, physiopathology)
- Lung Compliance
(drug effects)
- Meconium Aspiration Syndrome
(blood, pathology, physiopathology)
- Partial Pressure
- Pulmonary Surfactants
(pharmacology)
- Rabbits
- Swine
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