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Demyelinating neuropathy and acute lymphocytic leukemia.

Abstract
We report a 67-year-old man with acute lymphocytic leukemia (ALL) who developed a rapidly progressive areflexic quadriparesis following chemotherapy. Electrophysiologic studies demonstrated an acute demyelinating polyneuropathy. Although peripheral nervous system dysfunction in ALL is often attributed to leukemic infiltration or chemotherapy, a diligent search with electrophysiologic evaluation should be considered and may suggest alternative diagnoses.
AuthorsK C Gorson, K B Miller, D C Preston
JournalLeukemia (Leukemia) Vol. 7 Issue 3 Pg. 466-8 (Mar 1993) ISSN: 0887-6924 [Print] England
PMID8445952 (Publication Type: Case Reports, Journal Article)
Topics
  • Action Potentials (physiology)
  • Aged
  • Demyelinating Diseases (complications, physiopathology)
  • Electrophysiology
  • Humans
  • Male
  • Motor Neurons (physiology)
  • Neural Conduction (physiology)
  • Neurons, Afferent (physiology)
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma (complications, physiopathology)

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