Clinical and histologic effects of topical treatments of vulval lichen sclerosus. A critical evaluation.

Abstract

A randomized study was conducted on 79 patients with vulval lichen sclerosus who were treated for three months with four topical drugs including testosterone (2%), progesterone (2%), clobetasol propionate (.05%) and a cream based preparation. To evaluate the efficacy of the treatments, patients were examined before and after therapy for symptoms, gross appearance of the lesions and histopathologic features. Patients treated with clobetasol had a better response than responses recorded in the other groups. Remission of symptoms occurred in 75% of patients treated with clobetasol compared to 20% treated with testosterone, 10% treated with progesterone and 10% treated with a cream based preparation. The clobetasol group was the only group with gross changes and histologic evaluations before and after treatment, that showed a highly significant difference (P < .001). In a condition characterized by epidermal atrophy, we observed a significant reduction in epidermal atrophy after treatment. This study suggests that clobetasol propionate (.05%) (a very potent topical steroid) is the therapy of choice in vulval lichen sclerosus.

• Authors: G L Bracco, P Carli, L Sonni, G Maestrini, A De Marco, G L Taddei, A Cattaneo
• Journal: The Journal of reproductive medicine (J Reprod Med) Vol. 38 Issue 1 Pg. 37-40 (Jan 1993) ISSN: 0024-7758 [Print] United States
• PMID: 8441129 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Vaginal Creams, Foams, and Jellies
• Testosterone
• Progesterone
• Clobetasol

Topics

• Administration, Topical
• Adult
• Aged
• Aged, 80 and over
• Clobetasol (administration & dosage, analogs & derivatives, therapeutic use)
• Female
• Humans
• Lichenoid Eruptions (drug therapy)
• Middle Aged
• Progesterone (administration & dosage, therapeutic use)
• Sclerosis (drug therapy)
• Testosterone (administration & dosage, therapeutic use)
• Vaginal Creams, Foams, and Jellies
• Vulva (pathology)
• Vulvar Diseases (drug therapy)