Bilineage hematopoietic inhibitor and T lymphocyte dysfunction in a patient with pure red cell aplasia, myasthenia gravis and thymoma.

Abstract

The case history, laboratory findings and clinical course of a patient with pure red cell aplasia (PRCA) combined with myasthenia gravis and thymoma are reported herein. In vitro study revealed bilineage complement-dependent IgG inhibitor(s) in both the granulocyte-macrophage and erythroblastic progenitor cells. His serum showed high anti-acetylcholine receptor antibody levels associated with activity of myasthenia gravis as well as PRCA. Patient history of thymectomy 7 years previously followed by extensive cutaneous candidiasis with abnormal T lymphocyte subsets (decreased T4/T8 ratio and increased number of activated T lymphocytes) in both the bone marrow and peripheral blood suggested primary T lymphocyte dysfunction, whereas the erythropoiesis was not inhibited by T lymphocytes. This case is of interest in the context of a possible immunological pathogenesis for other hematopoietic disorders, including some cases of aplastic anemia.

• Authors: T Murase
• Journal: Experimental hematology (Exp Hematol) Vol. 21 Issue 3 Pg. 451-5 (Mar 1993) ISSN: 0301-472X [Print] Netherlands
• PMID: 8440342 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibodies
• Antibodies, Monoclonal
• Immunoglobulin G
• Receptors, Cholinergic
• Complement System Proteins

Topics

• Antibodies (blood)
• Antibodies, Monoclonal (analysis, immunology)
• CD4-CD8 Ratio
• Complement System Proteins (physiology)
• Flow Cytometry
• Granulocytes (cytology)
• Hematopoiesis (physiology)
• Hematopoietic Stem Cells (drug effects)
• Humans
• Immunoglobulin G (analysis)
• Macrophages (cytology)
• Male
• Middle Aged
• Myasthenia Gravis (complications, pathology, physiopathology)
• Receptors, Cholinergic (analysis, immunology)
• Red-Cell Aplasia, Pure (complications, pathology, physiopathology)
• Stem Cells (drug effects)
• T-Lymphocyte Subsets (immunology, pathology, physiology)
• T-Lymphocytes (pathology, physiology, ultrastructure)
• Thymoma (complications, pathology, physiopathology)
• Thymus Neoplasms (complications, pathology, physiopathology)