HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Prophylactic efficacy of tilmicosin for bovine respiratory tract disease.

Abstract
The prophylactic administration of injectable tilmicosin for pneumonia in weaned beef calves was investigated in 1,806 animals. Comparisons were made among calves receiving an "on-arrival" injection of tilmicosin, calves receiving a single injection of long-acting oxytetracycline, and calves receiving no prophylaxis. Morbidity and mortality attributable to pneumonia, morbidity and mortality attributable to all causes, and case fatality were significantly lower in the group of calves that received tilmicosin, compared with calves that received long-acting oxytetracycline and calves that received no prophylactic antibiotic. Mean time to initial pneumonia treatment was significantly extended in calves that received prophylaxis, compared with those that received no antibiotic on arrival at the feedlot. Calves that received tilmicosin gained significantly more weight than calves that received oxytetracycline. Calves that were not treated for pneumonia during the trial period gained significantly more weight than did those calves that were treated for pneumonia regardless of experimental group. The majority of mortalities were attributable to fibrinous pneumonia (31/34). Important bacterial isolates (Pasteurella spp, Haemophilus somnus, Actinomyces pyogenes) obtained at necropsy did not have resistance to tilmicosin in association with administration of tilmicosin as prophylaxis for pneumonia. However, bacterial resistance to trimethoprim/sulfonamide and to oxytetracycline were commonly found in these postmortem isolates.
AuthorsD W Morck, J K Merrill, B E Thorlakson, M E Olson, L V Tonkinson, J W Costerton
JournalJournal of the American Veterinary Medical Association (J Am Vet Med Assoc) Vol. 202 Issue 2 Pg. 273-7 (Jan 15 1993) ISSN: 0003-1488 [Print] United States
PMID8428833 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Bacterial Agents
  • Macrolides
  • Oxytetracycline
  • tilmicosin
  • Tylosin
Topics
  • Animals
  • Anti-Bacterial Agents
  • Cattle
  • Cattle Diseases (prevention & control)
  • Injections (veterinary)
  • Macrolides
  • Male
  • Oxytetracycline (administration & dosage, therapeutic use)
  • Pneumonia (prevention & control, veterinary)
  • Respiratory Tract Infections (prevention & control, veterinary)
  • Tylosin (administration & dosage, analogs & derivatives, therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: