Indium-111-labeled polyclonal human immunoglobulin: identifying focal infection in patients positive for human immunodeficiency virus.

Abstract

Pooled human immunoglobulin labeled with indium-111 (111In-HIgG) was used to identify the presence and extent of infection in patients positive for human immunodeficiency virus (HIV), presenting with either symptoms and/or signs of acute chest infection or with pyrexia without localizing signs or symptoms. Fifty-five studies were performed in 51 patients with suspected chest infection or pyrexia without localizing signs. Of these, 111In-HIgG identified intrapulmonary accumulation in 17 patients with Pneumocystis carinii pneumonia, eight with bacterial pneumonia, five with cytomegalovirus pneumonia, three with pulmonary Mycobacterium avium intracellulare infection and one with a fungal pneumonia. There was no intrapulmonary accumulation of 111In-HIgG in five patients with bronchopulmonary Kaposi's sarcoma and in three patients with intrathoracic lymphoma. Quantification of lung/heart activity was significantly increased (p < 0.05) in patients with active chest infection compared with those with intrapulmonary tumor or no active lung pathology. Indium-111-HIgG scintigraphy also localized at 14 sites of extrapulmonary infection, including six patients with colitis. There were no false-negative studies but false-positive uptake was seen in four studies. These results confirm that 111In-HIgG correctly identifies the presence and extent of infection in patients positive for HIV antibody.

• Authors: J R Buscombe, W J Oyen, A Grant, R A Claessens, J van der Meer, F H Corstens, P J Ell, R F Miller
• Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine (J Nucl Med) Vol. 34 Issue 10 Pg. 1621-5 (Oct 1993) ISSN: 0161-5505 [Print] United States
• PMID: 8410271 (Publication Type: Journal Article)

Chemical References

• Immunoglobulin G
• Indium Radioisotopes

Topics

• AIDS-Related Opportunistic Infections (diagnostic imaging)
• Adolescent
• Adult
• Female
• Focal Infection (complications, diagnostic imaging)
• HIV Seropositivity (complications)
• Humans
• Immunoglobulin G
• Indium Radioisotopes
• Male
• Middle Aged
• Pneumonia (diagnostic imaging)
• Pneumonia, Pneumocystis (diagnostic imaging)
• Prospective Studies
• Radioimmunodetection
• Sensitivity and Specificity