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The metabolic effects of limbic leucotomy in Gilles de la Tourette syndrome.

Abstract
Regional cerebral oxygen metabolism was measured before and after limbic leucotomy in a patient with Gilles de la Tourette syndrome, obsessive compulsive disorder, and obsessional slowness. The preoperative scan showed hypermetabolism in the caudate nuclei, which normalised after operation. It is proposed that the beneficial effects of this operation on both tics and obsessive compulsive behaviour are mediated by disruption of abnormal neural activity in basal ganglia-thalamocortical loops.
AuthorsG V Sawle, A J Lees, N F Hymas, D J Brooks, R S Frackowiak
JournalJournal of neurology, neurosurgery, and psychiatry (J Neurol Neurosurg Psychiatry) Vol. 56 Issue 9 Pg. 1016-9 (Sep 1993) ISSN: 0022-3050 [Print] England
PMID8410025 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Oxygen
Topics
  • Brain (metabolism)
  • Electrocoagulation
  • Humans
  • Limbic System (surgery)
  • Male
  • Middle Aged
  • Oxygen (metabolism)
  • Tomography, Emission-Computed
  • Tourette Syndrome (metabolism, surgery)

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