[Determination of neutrophil function in the respiratory infection by chemiluminescence (CL). I: Change in neutrophil's CL by chemotherapy against the bacterial pneumonia].

Abstract

We measured neutrophil's CL (CL-index) in 12 patients of the bacterial pneumonia three times per each case: before, during and after chemotherapy. Before the initiation of chemotherapy. CL-index in the six patients remained higher than that in healthy controls, while the remaining six showed lower levels of CL-index compared to the controls. In the 11 cases, their CL-indexes fell to levels lower than those obtained before treatment. Additionally, in the 11 cases their CL-indexes increased after the termination of chemotherapy. Furthermore, in the nine cases the product of the neutrophil number and CL-index was decreased by chemotherapy, and the decrease in the product correlated with improvement in their clinical conditions.

• Authors: S Takeuchi, M Sawaki, K Mikasa, M Konishi, K Maeda, M Sakamoto, K Hamada, M Kunimatsu, N Narita, E Kita
• Journal: Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases (Kansenshogaku Zasshi) Vol. 67 Issue 8 Pg. 697-703 (Aug 1993) ISSN: 0387-5911 [Print] Japan
• PMID: 8409576 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Anti-Bacterial Agents

Topics

• Adolescent
• Adult
• Aged
• Anti-Bacterial Agents (therapeutic use)
• Female
• Humans
• Luminescent Measurements
• Male
• Middle Aged
• Neutrophils (drug effects, physiology)
• Pneumonia (drug therapy, immunology, microbiology)