Abstract | OBJECTIVES: This study was designed to characterize immediate, early and long-term changes in right ventricular structure and function, as defined by two-dimensional and Doppler echocardiography, after single- lung transplantation in patients with severe pulmonary hypertension. BACKGROUND: METHODS: Fourteen patients with severe pulmonary hypertension who underwent single- lung transplantation were studied with transthoracic and transesophageal two-dimensional and Doppler echocardiography. Right ventricular dimensions were measured in the apical four-chamber view. Right ventricular ejection and acceleration times and peak velocity of tricuspid regurgitation were measured by Doppler study. Results of right heart catheterization were available early (< 3 months) after transplantation in 10 of 13 patients and late after transplantation (6 months to 2 years) in 11 patients. RESULTS: In the early posttransplantation studies, right ventricular dimensions decreased and fractional area change and ejection fraction increased in all patients, but right ventricular wall thickness did not change significantly. Tricuspid regurgitation lessened markedly in all patients. Long-term decreases in right ventricular dimension and improvement in systolic function were sustained. Right ventricular wall thickness significantly decreased compared with the early postoperative value (0.76 +/- 0.1 cm compared with 0.63 +/- 0.14 cm, p < 0.02). CONCLUSIONS:
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Authors | M Ritchie, A D Waggoner, V G Dávila-Román, B Barzilai, E P Trulock, P R Eisenberg |
Journal | Journal of the American College of Cardiology
(J Am Coll Cardiol)
Vol. 22
Issue 4
Pg. 1170-4
(Oct 1993)
ISSN: 0735-1097 [Print] United States |
PMID | 8409056
(Publication Type: Journal Article)
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Topics |
- Cardiac Catheterization
- Diastole
- Echocardiography
- Female
- Follow-Up Studies
- Hemodynamics
- Humans
- Hypertension, Pulmonary
(complications, diagnostic imaging, pathology, physiopathology)
- Lung Transplantation
(physiology)
- Male
- Postoperative Complications
(diagnostic imaging, pathology, physiopathology)
- Severity of Illness Index
- Stroke Volume
- Systole
- Time Factors
- Tricuspid Valve Insufficiency
(complications, diagnostic imaging, physiopathology)
- Ventricular Function, Right
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