Abstract |
Growth hormone-binding protein (GHBP) was studied in 11 girls with true precocious puberty, aged 7.3 +/- 0.2 years (mean +/- SE), before and after the first 6 months of treatment with luteinizing hormone-releasing hormone analogue D-Trp6-LHRH. The 125I-human GH was incubated with 150 microliters of serum, bound and free GH were separated by gel filtration. The levels of GHBP increased significantly from 24.2 +/- 1.3 to 28.1 +/- 1.9% (p < 0.002, paired t test), more than expected for the normal age-dependent increase. The efficiency of LHRH-A therapy was confirmed by a decrease in growth rate and normalization of clinical and biological parameters. Our data agree with the hypothesis that the pubertal spurt is mediated by a sex- steroid-induced rise in GH concentration, and they suggest that the levels of GHBP may be related to the GH secretion and its variation with treatment.
|
Authors | S B Oliveira, M Donnadieu, J L Chaussain |
Journal | Hormone research
(Horm Res)
Vol. 39
Issue 1-2
Pg. 42-6
( 1993)
ISSN: 0301-0163 [Print] Switzerland |
PMID | 8406338
(Publication Type: Journal Article)
|
Chemical References |
- Carrier Proteins
- Delayed-Action Preparations
- Triptorelin Pamoate
- Luteinizing Hormone
- Follicle Stimulating Hormone
- Growth Hormone
- somatotropin-binding protein
|
Topics |
- Carrier Proteins
(blood)
- Child
- Delayed-Action Preparations
- Female
- Follicle Stimulating Hormone
(blood)
- Growth
(drug effects)
- Growth Hormone
(blood)
- Humans
- Luteinizing Hormone
(blood)
- Puberty, Precocious
(blood, drug therapy, pathology)
- Triptorelin Pamoate
(administration & dosage, therapeutic use)
|