Dosage dependent modifiers of white alleles in Drosophila melanogaster.

Abstract

As part of a study to identify dosage-sensitive modifiers of the white eye colour locus and the retrotransposon, copia, a segmental aneuploid screen was conducted. It surveys the autosomal complement of the genome for dosage dependent modifiers of white, including ones effective upon retrotransposon insertion-induced alleles. Several regions were found which, when present as a segmental trisomy, affected one or more of the alleles tested in a strong and consistent fashion. Two of these regions have been identified as containing previously described modifiers, Darkener-of-apricot and Inverse regulator-a. The remainder identify new white allele modifiers. Selected segmental monosomics were also tested where possible for regions exhibiting a trisomic effect. At least three regions were found to have a dosage-dependent effect in one, two and three copies.

• Authors: J F Sabl, J A Birchler
• Journal: Genetical research (Genet Res) Vol. 62 Issue 1 Pg. 15-22 (Aug 1993) England
• PMID: 8405989 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Topics

• Alleles
• Animals
• Chromosomes
• Drosophila melanogaster (genetics)
• Eye Color (genetics)
• Female
• Trisomy (genetics)