Abstract |
The CD38 antigen displays restricted functional associations with surface molecules involved in immune system and complement. Capping of the CD38 molecule in normal or neoplastic T cells is followed by rapid and specific co-modulation of the CD3-T cell receptor (TcR) complex. In normal and tumor cells of B lineage, CD38 was found to be also associated with surface Ig (sIg) and with the complement receptor 2 (CR2)/CD19 complex. The CD38 molecule expressed by purified natural killer cells displayed an association with the low affinity IgG Fc receptor ( Fc gamma RIII) CD16. These observations suggest that specialized areas in the plasma membrane contain co-modulating structures, including different receptors involved in the transduction of extracellular signals. We propose a model whereby TcR, CR2 and CD16 are ligand binding structures in their respective lineages, while CD38 is a molecule involved in the intracellular transduction of the signals.
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Authors | A Funaro, L B De Monte, U Dianzani, M Forni, F Malavasi |
Journal | European journal of immunology
(Eur J Immunol)
Vol. 23
Issue 10
Pg. 2407-11
(Oct 1993)
ISSN: 0014-2980 [Print] Germany |
PMID | 8405040
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antigens, CD
- Antigens, Differentiation
- Membrane Glycoproteins
- Receptors, Antigen, B-Cell
- Receptors, Complement
- ADP-ribosyl Cyclase
- CD38 protein, human
- ADP-ribosyl Cyclase 1
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Topics |
- ADP-ribosyl Cyclase
- ADP-ribosyl Cyclase 1
- Antigens, CD
- Antigens, Differentiation
(metabolism)
- B-Lymphocytes
(immunology)
- Cell Line
- Cell Membrane
(immunology)
- Child
- Humans
- Immunologic Capping
- In Vitro Techniques
- Killer Cells, Natural
(immunology)
- Membrane Glycoproteins
- Receptors, Antigen, B-Cell
(metabolism)
- Receptors, Complement
(metabolism)
- Signal Transduction
(immunology)
- T-Lymphocytes
(immunology)
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