[Perioperative use of ampicillin/sulbactam, cefoxitin and piperacillin/ metronidazole in elective colon and rectal surgery. A prospective randomized quality assurance study of 422 patients].

Abstract

As has been proved before, antibiotic prophylaxis is highly effective in lowering wound infection rates in colorectal surgery. In order to establish quality control, we checked the effectiveness of three different prophylactic antibiotic regimes in 422 patients in a prospective and randomized trial. Between the three groups were no significant differences as regards age, type of operation and risk factors like adipositas and diabetes. The wound infection rate according to CDC-criteria was from 7.0 to 9.5%. We did not find a significant difference between the three antibiotic regimes. It is therefore our conclusion, that in our setting each of the three different types of antibiotics is of equal value. This means, on the other hand, that the cheapest one is enough.

• Authors: J Menzel, J Bauer, E von Pritzbuer, I Klempa
• Journal: Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen (Chirurg) Vol. 64 Issue 8 Pg. 649-52 (Aug 1993) ISSN: 0009-4722 [Print] Germany
• Vernacular Title: Perioperative Anwendung von Ampicillin/Sulbactam, Cefoxitin und Piperacillin/Metronidazol in der elektiven Colon- und Rectumchirurgie. Eine prospektive randomisierte Qualitätssicherungsstudie bei 422 Patienten.
• PMID: 8404293 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Bacterial Agents
• Metronidazole
• Cefoxitin
• Ampicillin
• Sulbactam
• Piperacillin

Topics

• Aged
• Ampicillin (administration & dosage)
• Anti-Bacterial Agents (administration & dosage, adverse effects)
• Bacterial Infections (prevention & control)
• Cefoxitin (administration & dosage, adverse effects)
• Colitis, Ulcerative (surgery)
• Colonic Polyps (surgery)
• Colorectal Neoplasms (surgery)
• Diverticulitis, Colonic (surgery)
• Drug Therapy, Combination (adverse effects, therapeutic use)
• Elective Surgical Procedures
• Female
• Humans
• Male
• Metronidazole (administration & dosage, adverse effects)
• Middle Aged
• Piperacillin (administration & dosage, adverse effects)
• Premedication
• Prospective Studies
• Quality Assurance, Health Care
• Sulbactam (administration & dosage)
• Surgical Wound Infection (prevention & control)