Protein S deficiency in a patient with necrotizing cellulitis.

A case of necrotizing cellulitis of the penis is reported. In this patient, transient functional protein S deficiency during the infectious process was demonstrated with a marked decrease of free protein S and elevated C4b-binding protein levels. Moreover, by investigating other members of this patient's family it was possible to demonstrate a subclinical inherited protein S deficiency. In this study it is suggested that the profound and transient decrease of functional protein S observed in this patient during infectious cellulitis, may have contributed to the pathogenesis of tissue necrosis.
AuthorsP Joly, O Chosidow, M Gouault-Heilmann, M Levent, J C Roujeau, J Revuz
JournalClinical and experimental dermatology (Clin Exp Dermatol) Vol. 18 Issue 4 Pg. 305-8 (Jul 1993) ISSN: 0307-6938 [Print] ENGLAND
PMID8403462 (Publication Type: Case Reports, Journal Article)
  • Adult
  • Cellulitis (etiology, immunology, pathology)
  • Humans
  • Male
  • Necrosis
  • Penile Diseases (etiology, immunology, pathology)
  • Penis (pathology)
  • Protein S Deficiency

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