Abstract |
A case of necrotizing cellulitis of the penis is reported. In this patient, transient functional protein S deficiency during the infectious process was demonstrated with a marked decrease of free protein S and elevated C4b-binding protein levels. Moreover, by investigating other members of this patient's family it was possible to demonstrate a subclinical inherited protein S deficiency. In this study it is suggested that the profound and transient decrease of functional protein S observed in this patient during infectious cellulitis, may have contributed to the pathogenesis of tissue necrosis.
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Authors | P Joly, O Chosidow, M Gouault-Heilmann, M Levent, J C Roujeau, J Revuz |
Journal | Clinical and experimental dermatology
(Clin Exp Dermatol)
Vol. 18
Issue 4
Pg. 305-8
(Jul 1993)
ISSN: 0307-6938 [Print] England |
PMID | 8403462
(Publication Type: Case Reports, Journal Article)
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Topics |
- Adult
- Cellulitis
(etiology, immunology, pathology)
- Humans
- Male
- Necrosis
- Penile Diseases
(etiology, immunology, pathology)
- Penis
(pathology)
- Protein S Deficiency
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