[The regression of left ventricular hypertrophy and improvement in diastolic filling during antihypertensive therapy with cilazapril].

Abstract

In order to evaluate the effects of cilazapril on left structure and function in essential hypertension, we evaluated 10 patients (4 females and 6 males) affected with mild-to-moderate systemic hypertension. All patients were treated with cilazapril 5 mg/day over a 6-months period and underwent a 24 hours ambulatory blood pressure monitoring and a complete Doppler echocardiographic examination at study entry, after 3 and 6-months of therapy. After therapy, mean systolic and diastolic arterial pressure decreased significantly from 153 +/- 16/102 +/- 8 mmHg to 135 +/- 13/83 +/- 6 mmHg respectively (p < 0.005/0.001 respectively). Moreover there was a significant decrease of left ventricular mass from 109 +/- 27 to 87 +/- 23 g/m2 (p < 0.005). Ejection phase indices did not change significantly, whereas left ventricular diastolic filling improved after therapy with a significant increase of M1/M2 ratio from 0.9 +/- 0.2 to 1.1 +/- 0.3 (p < 0.02). In conclusion, these data demonstrate that cilazapril 5 mg/day is effective in reducing blood pressure in mild-to-moderate essential hypertension. This normalization of blood pressure measurements is paralleled by a significant decrease of left ventricular mass index and by an improvement of left ventricular diastolic filling.

• Authors: D Sabatini, S Fazio, A Cittadini, B Biondi, A Lucariello, T Picano, L Saccà
• Journal: Cardiologia (Rome, Italy) (Cardiologia) Vol. 38 Issue 6 Pg. 377-81 (Jun 1993) ISSN: 0393-1978 [Print] Italy
• Vernacular Title: Regressione dell'ipertrofia e miglioramento del riempimento diastolico ventricolare sinistro in corso di terapia antipertensiva con cilazapril.
• PMID: 8402747 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article)

Chemical References

• Cilazapril

Topics

• Adult
• Analysis of Variance
• Cilazapril (therapeutic use)
• Diastole (drug effects)
• Female
• Humans
• Hypertension (diagnosis, drug therapy, epidemiology, physiopathology)
• Hypertrophy, Left Ventricular (diagnosis, drug therapy, epidemiology, physiopathology)
• Male
• Middle Aged
• Remission Induction