Effect of hypertriglyceridemia correction by omega-3 fatty acids on peritoneal transport in continuous ambulatory peritoneal dialysis patients.

Abstract

Lipid abnormalities, both hypercholesterolemia and particularly hypertriglyceridemia (hyperTg), are common in long-term continuous ambulatory peritoneal dialysis (CAPD) patients. Hyperviscosity and rheological alterations have been proposed as major hemodynamic problems in hyperTg patients. The aim of this study was to evaluate whether a hyperTg correction by employing omega-3 fatty acids (omega-3) affects peritoneal transport. Six hyperTg (> 700 mg/dL) CAPD patients were treated with 2-3 g/day of omega-3 until normal Tg values were achieved. The assessment of peritoneal dialysis efficacy was performed by evaluating the peritoneal equilibration test (PET) before omega-3 supplementation, when normal Tg levels were reached, and 3 weeks after stopping therapy when hyperTg returned. When normal Tg levels were reached, a small but significant improvement of urea and creatinine D/P was noted: 0.85 +/- 0.05 versus 0.93 +/- 0.03 (p < 0.05) and 0.78 +/- 0.03 versus 0.86 +/- 0.05 (p < 0.05), respectively, with negative correlation between D/P of urea and Tg. These preliminary data demonstrate that a hyperTg correction with omega-3 may induce an increase in peritoneal transport of small molecules in CAPD.

• Authors: A Fracasso, P Toffoletto, S Landini, P Morachiello, F Righetto, F Scanferla, R Genchi, D Roncali, G Bazzato
• Journal: Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis (Perit Dial Int) Vol. 13 Suppl 2 Pg. S437-9 ( 1993) ISSN: 0896-8608 [Print] United States
• PMID: 8399634 (Publication Type: Journal Article)

Chemical References

• Fatty Acids, Omega-3
• Lipids
• Triglycerides
• Urea
• Creatinine
• Glucose

Topics

• Aged
• Biological Transport (drug effects)
• Creatinine (metabolism)
• Fatty Acids, Omega-3 (therapeutic use)
• Female
• Glucose (metabolism)
• Humans
• Hypertriglyceridemia (drug therapy, etiology, metabolism)
• Lipids (blood)
• Male
• Middle Aged
• Peritoneal Dialysis, Continuous Ambulatory (adverse effects)
• Peritoneum (metabolism)
• Triglycerides (blood)
• Urea (metabolism)