Nonoxynol-9 protects mice against vaginal transmission of genital herpes infections.

Abstract

A vaginal application of a commercially available contraceptive jelly containing nonoxynol-9 (N9) prevented vaginal transmission of herpes simplex virus type 2 (HSV-2) infections in the mouse. When N9 jelly was delivered to the vagina with the virus inoculum, 20 s before inoculum, or 5 min before inoculum, mice were completely protected from visible infection (P < .001). Protection lasted for at least 30 min (P < .03), and significant protection occurred even when the N9 jelly was delivered 15 min after the HSV-2 inoculum (P < .05). These results are consistent with results of studies using N9 products in other animal models and suggest that N9-based contraceptive products can provide significant protection against vaginal transmission of enveloped virus infections in animals.

• Authors: K J Whaley, R A Barratt, L Zeitlin, T E Hoen, R A Cone
• Journal: The Journal of infectious diseases (J Infect Dis) Vol. 168 Issue 4 Pg. 1009-11 (Oct 1993) ISSN: 0022-1899 [Print] United States
• PMID: 8397261 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Nonoxynol
• Medroxyprogesterone Acetate

Topics

• Animals
• Female
• Herpes Genitalis (prevention & control, transmission)
• Humans
• Medroxyprogesterone Acetate (pharmacology)
• Mice
• Mice, Inbred C57BL
• Nonoxynol (therapeutic use)
• Pregnancy
• Pregnancy Complications, Infectious (microbiology)
• Sexually Transmitted Diseases (prevention & control, transmission)
• Simplexvirus (isolation & purification)
• Vagina (microbiology)